The eyebrow sign: A distinctive sonographic appearance of calcified Peyronie's plaques

Peyronie’s disease is a fibrotic disorder of the tunica albuginea characterized by plaque formation, penile curvature and erectile dysfunction. We report a 50-year-old man with a hard palpable nodule on the dorsal aspect of the penis. High-frequency transverse ultrasound demonstrated a curvilinear hyperechoic calcified tunical plaque with posterior acoustic shadowing, resembling the contour of an eyebrow. We propose the term “Eyebrow Sign” for this distinctive sonographic appearance of calcified Peyronie’s plaque, which appears to be underreported in the existing literature. Recognition of this sign may facilitate confident identification of chronic disease, improve reporting consistency and serve as an educational tool in penile imaging. • Introduces a distinctive sonographic descriptor — the “Eyebrow Sign” — for calcified Peyronie’s plaque. • The Eyebrow Sign represents a curvilinear hyperechoic tunical plaque with posterior acoustic shadowing resembling a human eyebrow. • Recognition of this sign can enhance diagnostic confidence and reporting consistency in penile imaging. • The sign has been reproducibly observed in multiple independent cases on Radiopaedia, supporting its validity. • May serve as an educational tool for radiologists and urologists in identifying chronic calcified plaques.