Expedited Kinetic Modeling Workflow Leveraging Medium-Throughput Automation

The generation and application of kinetic models are of significant interest to process chemists, as they can enable rationale-driven process development, model-based optimization, and bolster and codify process understanding. However, there is a current critical gap in laboratory automation technologies in the gathering of representative, data-rich kinetic data at reasonable throughput to support the early and broad deployment of kinetic models. The novel ReactAll workstation seeks to close this gap. Herein, an evaluation of this workstation was carried out to investigate its suitability within the context of kinetic modeling activities. As a result, a kinetic model for an acid-catalyzed diethyl acetal deprotection process was developed that unexpectedly supported quinolinium species to be catalytically active.