Recurrent Resistance Mutations to Lirafugratinib Inform Treatment Sequencing in <i>FGFR2</i> -Driven Tumors
The complementary activity of lirafugratinib and futibatinib against FGFR2 kinase domain mutations supports their sequential use, when precise resistance mutations are detected in patients.
Authors
- Alice Da Silva
- Sophie Cotteret (ORCID: https://orcid.org/0000-0001-5598-0112)
- L. Tselikas
- Cristina Smolenschi (ORCID: https://orcid.org/0000-0002-7568-6196)
- Elsa Bernard (ORCID: https://orcid.org/0000-0002-2057-7187)
- Luc Friboulet (ORCID: https://orcid.org/0000-0002-1129-4978)
- Ken A. Olaussen (ORCID: https://orcid.org/0000-0002-3115-8914)
- Dong Man Jang (ORCID: https://orcid.org/0000-0003-0701-0503)
- C. Nicotra
- Michael J. Eck (ORCID: https://orcid.org/0000-0003-4247-9403)
- Floriane Brayé (ORCID: https://orcid.org/0009-0002-3527-6771)
- Héloïse Bourien (ORCID: https://orcid.org/0000-0001-8979-3972)
- Alice Boilève (ORCID: https://orcid.org/0000-0003-3708-4909)
- Rémy Barbé (ORCID: https://orcid.org/0009-0008-4643-4492)
- Miguel P. Soares (ORCID: https://orcid.org/0000-0002-9314-4833)
- Inmaculada Alonso-García
- Catline Nobre
- Ludovic Bigot (ORCID: https://orcid.org/0009-0009-0820-5370)
- Damien Vasseur (ORCID: https://orcid.org/0000-0001-8787-1498)
- F. André
- F. Facchinetti
- Seshiru Nakazawa (ORCID: https://orcid.org/0000-0001-6218-9396)
- Fernanda Mosele
- Cécile Badoual
- Melissandre Meteau
- Mathis Delavigne
- M. Ducreux
- Kristi Beshiri
- Sergey Nikolaev
- Antoine Hollebecque
- Juliette Samaniego
- Antoine Italiano
- Beatriz Alonso-De-Castro
- Julieta Rodriguez
- Yohann Loriot
- Maud Ngo-Camus
Institutions
- Harvard University (US)
- Université de Bordeaux (FR)
- Inserm (FR)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Centre Eugène Marquis (FR)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-4390
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00