Recurrent Resistance Mutations to Lirafugratinib Inform Treatment Sequencing in <i>FGFR2</i> -Driven Tumors

The complementary activity of lirafugratinib and futibatinib against FGFR2 kinase domain mutations supports their sequential use, when precise resistance mutations are detected in patients.

Authors

Institutions

Publication Details

Journal
Clinical Cancer Research
Published
2026-02-03
DOI
https://doi.org/10.1158/1078-0432.ccr-25-4390
Primary Topic
Fibroblast Growth Factor Research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Recurrent Resistance Mutations to Lirafugratinib Inform Treatment Sequencing in FGFR2 -Driven Tumors

Alice Da Silva, Sophie Cotteret, L. Tselikas, Cristina Smolenschi et al.
Clinical Cancer Research
Fibroblast Growth Factor Research
article

Recurrent Resistance Mutations to Lirafugratinib Inform Treatment Sequencing in FGFR2 -Driven Tumors

Alice Da Silva, Sophie Cotteret, L. Tselikas, Cristina Smolenschi, Elsa Bernard, Luc Friboulet, Ken A. Olaussen, Dong Man Jang, C. Nicotra, Michael J. Eck, Floriane Brayé, Héloïse Bourien, Alice Boilève, Rémy Barbé, Miguel P. Soares, Inmaculada Alonso-García, Catline Nobre, Ludovic Bigot, Damien Vasseur, F. André, F. Facchinetti, Seshiru Nakazawa, Fernanda Mosele, Cécile Badoual, Melissandre Meteau, Mathis Delavigne, M. Ducreux, Kristi Beshiri, Sergey Nikolaev, Antoine Hollebecque, Juliette Samaniego, Antoine Italiano, Beatriz Alonso-De-Castro, Julieta Rodriguez, Yohann Loriot, Maud Ngo-Camus
article en

Abstract

The complementary activity of lirafugratinib and futibatinib against FGFR2 kinase domain mutations supports their sequential use, when precise resistance mutations are detected in patients.

Clinical Cancer Research
Harvard University (US), Université de Bordeaux (FR), Inserm (FR), Université Paris-Saclay (FR), Institut Gustave Roussy (FR), Centre Eugène Marquis (FR), Dana-Farber Cancer Institute (US)
Good health and well-being
Openalex Percentile: Top 69%
Fibroblast Growth Factor Research
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.