Extrachromosomal DNA drives molecular and clinical heterogeneity in hepatocellular carcinoma: a multi-omics analysis and prognostic model development
Our study characterizes the molecular and clinical distinctions between ecDNA-negative and ecDNA-positive HCC and establishes a clinically applicable gene signature for patient prognosis. These findings advance our understanding of ecDNA-driven tumor heterogeneity and provide potential strategies for personalized HCC management.
Authors
- Fenfang Wu (ORCID: https://orcid.org/0000-0001-5588-8199)
- Guangquan Zhang (ORCID: https://orcid.org/0000-0002-4803-0693)
- Hu
- Xu J
- Yongfei He
- Kai Huang
- Hang Zhai
- Jicai Wang
- Shengjie Hong
- Xianjie Shi
Institutions
- Sun Yat-sen University (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Human Genomics
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1186/s40246-026-00927-w
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00