Calcium Dobesilate Interference in Two Urinary Total Protein Detection Methods

Calcium dobesilate did not significantly interfere with the pyrogallol red-molybdate method but did significantly interfere with the benzethonium chloride method. The direction and degree of interference were related to the urinary protein and drug concentrations. Discontinuing calcium dobesilate for 1-2 days before obtaining a urine sample for total protein detection is recommended.

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Publication Details

Journal
Journal of Clinical Laboratory Analysis
Published
2026-02-03
DOI
https://doi.org/10.1002/jcla.70155
Primary Topic
Advanced Proteomics Techniques and Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

Calcium Dobesilate Interference in Two Urinary Total Protein Detection Methods

Y. Songlin, Guo xiuzhi, X. Liangyu, Kui Zhang et al.
Journal of Clinical Laboratory Analysis
Advanced Proteomics Techniques and Applications
article

Calcium Dobesilate Interference in Two Urinary Total Protein Detection Methods

Y. Songlin, Guo xiuzhi, X. Liangyu, Kui Zhang, Qi Zhang, Ling Qiu, Zheng Mingqi, Xu Jingrong, Ma Xiaoli
article en

Abstract

Calcium dobesilate did not significantly interfere with the pyrogallol red-molybdate method but did significantly interfere with the benzethonium chloride method. The direction and degree of interference were related to the urinary protein and drug concentrations. Discontinuing calcium dobesilate for 1-2 days before obtaining a urine sample for total protein detection is recommended.

Journal of Clinical Laboratory AnalysisVol. 40(5)
Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking Union Medical College Hospital (CN), Longgang Central Hospital (CN)
Peking Union Medical College Hospital
Openalex Percentile: Top 70%
Advanced Proteomics Techniques and Applications
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