Salivary Duct Carcinoma: Report of an Advanced Challenging Case Diagnosed by Ultrasound‐Guided Fine‐Needle Aspiration Biopsy

We report a rare case of salivary duct carcinoma (SDC) in a 67-year-old male who presented with a rapidly enlarging, ill-defined left upper neck mass, accompanied by both cervical and axillary lymphadenopathy. Initial punch biopsy of the neck mass suggested metastatic breast carcinoma. However, ultrasound-guided fine-needle aspiration (US-FNA) and comprehensive immunohistochemical analysis, in conjunction with radiologic findings, confirmed the diagnosis of SDC. This case highlights the diagnostic challenges of SDC and reinforces the pivotal role of US-FNA cytology in establishing a definitive diagnosis while minimizing invasive procedures.

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Publication Details

Journal
Diagnostic Cytopathology
Published
2026-02-02
DOI
https://doi.org/10.1002/dc.70091
Primary Topic
Salivary Gland Tumors Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Salivary Duct Carcinoma: Report of an Advanced Challenging Case Diagnosed by Ultrasound‐Guided Fine‐Needle Aspiration Biopsy

Prerna Khetan, Maoxin Wu
Diagnostic Cytopathology
Salivary Gland Tumors Diagnosis and Treatment
article

Salivary Duct Carcinoma: Report of an Advanced Challenging Case Diagnosed by Ultrasound‐Guided Fine‐Needle Aspiration Biopsy

Prerna Khetan, Maoxin Wu
article en

Abstract

We report a rare case of salivary duct carcinoma (SDC) in a 67-year-old male who presented with a rapidly enlarging, ill-defined left upper neck mass, accompanied by both cervical and axillary lymphadenopathy. Initial punch biopsy of the neck mass suggested metastatic breast carcinoma. However, ultrasound-guided fine-needle aspiration (US-FNA) and comprehensive immunohistochemical analysis, in conjunction with radiologic findings, confirmed the diagnosis of SDC. This case highlights the diagnostic challenges of SDC and reinforces the pivotal role of US-FNA cytology in establishing a definitive diagnosis while minimizing invasive procedures.

Diagnostic Cytopathology
Stony Brook School (US)
Openalex Percentile: Top 69%
Salivary Gland Tumors Diagnosis and Treatment
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