In vitro evidence and integrative bioinformatics identify the SGLT2-PPARγ axis as a target against polyethylene microplastic-driven metabolic reprogramming in colorectal cancer cells
Results unveil the adverse effects of PE on CRC progression underscoring a dynamic interplay between environmental pollutants, metabolic regulators and dietary bioactive modulators. This evidence lay the groundwork for future studies on integrative approaches aimed at mitigating the effects of microplastic pollution on CRC.
Authors
- Anna Balestrieri (ORCID: https://orcid.org/0000-0001-6818-5628)
- Raffaele Marfella (ORCID: https://orcid.org/0000-0003-3960-9270)
- Celestino Sardu (ORCID: https://orcid.org/0000-0001-5099-3790)
- Vitale Del Vecchio
- Isabella Donisi
- Antonino Colloca
- Maria Luisa Balestrieri
- Nunzia D’Onofrio
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Istituto Zooprofilattico Sperimentale del Mezzogiorno (IT)
- Link Campus University (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1186/s12967-026-07776-0
- Primary Topic
- Microplastics and Plastic Pollution
- Type
- article
- Field-Weighted Citation Impact
- 0.00