Serum Klotho Levels, Brain Structure, and Cognitive Performance
Results suggest that circulating serum klotho levels modified the known adverse association between age-related brain atrophy and cognition in older, but not younger, adults at risk for AD, suggesting that the neuroprotective effects of klotho may be age dependent.
Authors
- Dena B. Dubal (ORCID: https://orcid.org/0000-0001-7504-4372)
- Yue Ma (ORCID: https://orcid.org/0000-0003-1362-3752)
- Barbara B. Bendlin (ORCID: https://orcid.org/0000-0002-0580-9875)
- Alec Czaplicki
- Ira Driscoll (ORCID: https://orcid.org/0000-0002-1737-3343)
- Sanjay Asthana
- Ozioma C. Okonkwo
- Sterling C. Johnson
- J. Max Gaitán
Institutions
- University of Wisconsin–Madison (US)
- University of California, San Francisco (US)
- Geriatric Research Education and Clinical Center (US)
- University of Wisconsin Health (US)
- William S. Middleton Memorial Veterans Hospital (US)
- Wisconsin Division of Public Health (US)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1001/jamaneurol.2025.5581
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00