Prediction of recent HIV-1 infections using Shannon entropy analysis of HIV-1 group-specific antigen protein sequence
Our data show that a Gag-based molecular strategy can be used to detect recent HIV-1 infections where Gag sequences are available. However, the results would have to be interpreted with caution due to an association with a high FRR. Further studies are needed to develop a molecular-based strategy with better performance for detection of recent HIV-1 infections.
Authors
- Paballo Nkone
- Shayne Loubser (ORCID: https://orcid.org/0000-0001-9718-4085)
- Simnikiwe H. Mayaphi
- Tumelo L Fortuin
- Caroline T. Tiemessen
Institutions
- Tshwane University of Technology (ZA)
- University of the Witwatersrand (ZA)
- University of Pretoria (ZA)
Publication Details
- Journal
- Virology Journal
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1186/s12985-026-03080-x
- Primary Topic
- Fractal and DNA sequence analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00