Unraveling the Antioxidant, Antihyperlipidemic, and Antidiabetic Potential of Jatropha integerrima in Streptozotocin-Induced Diabetic Rats

Diabetes <i>mellitus</i> (DM) is a chronic metabolic disorder associated with hyperglycemia, oxidative stress, and dyslipidemia, leading to severe complications. Medicinal plants like <i>Jatropha integerrima</i>, known for their antioxidant and therapeutic properties, are being explored as potential alternatives for the management of diabetes. The present study aimed to evaluate the antidiabetic, antihyperlipidemic, and antioxidant effects of the methanolic extract of <i>Jatropha integerrima</i> (MEJI) in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in Wistar rats using STZ (45 mg/kg, i.p.), followed by oral treatment with MEJI (200 and 400 mg/kg) or metformin (200 mg/kg) for 21 days. Glycemic control was assessed through fasting blood glucose level (FBG), and the oral glucose tolerance test (OGTT), lipid profiling (TC, TG, LDL, HDL, and VLDL), and antioxidant (SOD and CAT) testing were outsourced to UNIQUE Biodiagnostics Vet. Path Lab, Parel, Maharashtra, while pancreatic histopathology was analyzed by evaluating islet morphology. Treatment with MEJI produced a dose-dependent reduction in fasting blood glucose levels. On day 21, MEJI at 200 and 400 mg/kg reduced blood glucose by 63.1% and 67.0%, respectively, compared to the diabetic control group. The standard drug showed the highest reduction (73.6%), restoring glucose levels close to normal values, compared with the diabetic control group, along with an improvement in glucose tolerance as reflected in OGTT outcomes. Moreover, the extract also favorably modulated the lipid profile by lowering TC, TG, LDL, and VLDL levels while enhancing HDL concentrations. Antioxidant enzyme activities improved notably, with significant elevations in SOD and CAT levels, indicating attenuation of oxidative stress. Furthermore, the histopathological examination of pancreatic sections revealed partial recovery of islet architecture in MEJI-treated rats, suggesting regenerative and protective effects on pancreatic β-cells. MEJI exhibited potent glucose-lowering, lipid-regulating, and antioxidant properties, along with pancreatic protection. These findings suggest that <i>Jatropha integerrima</i> may serve as a reservoir of bioactive compounds with promising potential for the management of diabetes.