Construction and application of a genetically engineered mouse model of gastric adenocarcinoma
We successfully established a spontaneous GAC model and its corresponding cell line in C57BL/6J mice, enabling a comprehensive investigation of tumor progression, metastasis, therapeutic response, and resistance mechanisms in vivo. This model represents a valuable platform for advancing precision medicine in gastric cancer.
Authors
- Yelizhati Madeti
- Xiaoyi Chong
- Xiaotian Zhang
Institutions
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Ministry of Education (ET)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Journal of the Chinese Medical Association
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1097/jcma.0000000000001350
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00