Hexadecanamide alleviates experimental colitis in mice and modifies the gut microbiome
Overall, our findings suggest that HEX markedly ameliorates DSS-induced colitis by limiting inflammation, improving barrier integrity and regulating gut microbial composition. These results highlight the critical role of HEX in maintaining intestinal homeostasis and suggest its potential as a novel preventive and therapeutic strategy.
Authors
- Caijun Zhao (ORCID: https://orcid.org/0000-0002-6435-8437)
- Hongyang Jiang (ORCID: https://orcid.org/0000-0003-0287-8581)
- Yihong Zhao
- Ruping Shan
- Keyi Wu (ORCID: https://orcid.org/0009-0005-4204-6407)
- Wenchao Bian
- Yunhe Fu
- Shan Shang
- Yu Han
- Yi Liu
- Lei JIN
- Lijuan Bao
- yang yang
- Xiaoyu Hu
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1186/s12915-026-02530-w
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00