Deep characterization of refractory epilepsy due to mild malformation of cortical development with oligodendroglial hyperplasia ( <scp>MOGHE</scp> ) and insights into the role of invasive monitoring

Our results underscore the pivotal role of SEEG in enhancing surgical outcomes in patients with drug-resistant epilepsy due to MOGHE. SEEG proved particularly beneficial in defining resection margins, especially in cases where non-invasive data were discordant, scalp EEG patterns were generalized or poorly localized, and imaging findings were nonspecific, diffuse, or normal, making lesion identification challenging.

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Publication Details

Journal
Epilepsia
Published
2026-02-02
DOI
https://doi.org/10.1002/epi.70118
Primary Topic
Epilepsy research and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Deep characterization of refractory epilepsy due to mild malformation of cortical development with oligodendroglial hyperplasia ( MOGHE ) and insights into the role of invasive monitoring

Demitre Serletis, Juan Bulacio, Balu Krishnan, Jean Khoury et al.
Epilepsia
Epilepsy research and treatment
article

Deep characterization of refractory epilepsy due to mild malformation of cortical development with oligodendroglial hyperplasia ( MOGHE ) and insights into the role of invasive monitoring

Demitre Serletis, Juan Bulacio, Balu Krishnan, Jean Khoury, Ingmar Blümcke, William Bingaman, Imad Najm, Robyn M. Busch
article en

Abstract

Our results underscore the pivotal role of SEEG in enhancing surgical outcomes in patients with drug-resistant epilepsy due to MOGHE. SEEG proved particularly beneficial in defining resection margins, especially in cases where non-invasive data were discordant, scalp EEG patterns were generalized or poorly localized, and imaging findings were nonspecific, diffuse, or normal, making lesion identification challenging.

Epilepsia
Cleveland Clinic (US), Universitätsklinikum Erlangen (DE)
Peace, Justice and strong institutions
Openalex Percentile: Top 70%
Epilepsy research and treatment
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