Age and sex influence transcriptomic responses to statin therapy that control liver aging during systemic metabolic dysfunction
Age-dependent transcriptional remodeling in the liver differs in statin users and non-users. Pathways involved in senescence are suppressed while those that promote ferroptosis are induced in statin users. These results suggest that statins may suppress biological aging in MASLD by acting as senolytics and highlight the complex, context-specific roles of senescence in liver adaptation and remodeling.
Authors
- Manal F. Abdelmalek (ORCID: https://orcid.org/0000-0002-5001-8618)
- Seh Hoon Oh (ORCID: https://orcid.org/0009-0006-3817-936X)
- David S. Umbaugh (ORCID: https://orcid.org/0000-0002-5327-9020)
- Kuo Du (ORCID: https://orcid.org/0000-0002-1446-4653)
- Georgia Sofia Karachaliou (ORCID: https://orcid.org/0000-0003-4091-3798)
- Rajesh Kumar Dutta (ORCID: https://orcid.org/0000-0002-1394-0961)
- Ayako Suzuki
- Anna Mae Diehl
- Liuyang Wang
Institutions
- Mayo Clinic (US)
- Duke University (US)
Publication Details
- Journal
- Hepatology
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1097/hep.0000000000001704
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00