Kisspeptin improves local ovarian insulin resistance in PCOS by modulating the PI3K/AKT/GLUT4 signaling pathway
Kisspeptin improves insulin resistance through the PI3K/AKT/GLUT4 signaling pathway and exerts its effects in vitro in granulosa cells. by protecting mitochondrial function. This study provides potential biomarkers and therapeutic targets for the treatment of PCOS-IR.
Authors
- HuaGang Ma
- Lilan Sun
- Na Sun (ORCID: https://orcid.org/0000-0003-4309-9517)
- Dandan Qi
- Pingping Sun
- Ping Sun
Institutions
- Weifang People's Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1371/journal.pone.0342158
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 0.00