Cardiovascular risk assessed using the SCORE system and blood renalase concentration in the Polish subpopulation of the PURE study

Prospective Urban and Rural Epidemiology (PURE) study is an international cohort study. Cardiovascular diseases (CVD) are a leading cause of death among worldwide. Several scales were developed to assess cardiovascular risk – one of them is SCORE system. Renalase is chemical compound which association with cardiovascular risk is likely but yet uncertain. The aim of this study was to assess the association between cardiovascular risk assessed using the SCORE system and blood renalase concentration in the Polish subpopulation of PURE study. The study group was composed of 269 participants (156 female and 113 male, 55.54 ± 7.99 years). Significant differences in blood renalase concentrations between different SCORE thresholds were found. Significant correlations between blood renalase concentrations and systolic blood pressure, as well as between blood renalase concentrations and SCORE were found. A blood renalase concentration above 84.02 ng/ml was shown to be the most accurate predictor of a SCORE < 1%. In summary, it was documented that higher blood renalase concentrations were associated with lower cardiovascular risk assessed using the SCORE system.