Pharmacological Depletion of Retinal Mononuclear Phagocytes Is Neuroprotective in a Mouse Model of Mitochondrial Optic Neuropathy
Pexidartinib effectively depletes retinal MNPs and is neuroprotective in the setting of severe RGC mitochondrial dysfunction. This therapeutic effect is additive to that of hypoxia. Combating retinal neuro-inflammation may therefore be a useful adjunct therapy in mitochondrial optic neuropathies like Leber hereditary optic neuropathy (LHON).
Authors
- Sandra S. Stinnett (ORCID: https://orcid.org/0000-0001-7192-0195)
- Hao Ying (ORCID: https://orcid.org/0000-0003-0824-9348)
- Avital L. Okrent Smolar
- Rahul Viswanath
- Sidney M. Gospe
- Howard M. Bomze
Institutions
- Duke University (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1167/iovs.67.2.6
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research to Prevent Blindness
- National Institutes of Health