Preclinical signal for a disease‐modifying effect on seizure cluster severity with intermittent diazepam treatment
Changes in several seizure cluster phenotypical parameters were suggestive of an enduring disease-modifying effect of diazepam, despite an apparent rebound effect of intermittent diazepam treatment on seizure frequency. Further study is warranted using a model incorporating a background antiseizure medication regimen to potentially attenuate the unexpected rebound seizures.
Authors
- Wesley T. Kerr (ORCID: https://orcid.org/0000-0002-5546-5951)
- Qian Wu (ORCID: https://orcid.org/0000-0002-2292-4816)
- Jonathan Vuong
- Leock Y. Stella. Ngo
- Michelle Guignet (ORCID: https://orcid.org/0000-0003-4788-0175)
- Adrián L. Rabinowicz (ORCID: https://orcid.org/0000-0003-1299-0606)
- Evelyn K. Shih (ORCID: https://orcid.org/0000-0002-8455-0231)
- H. Steve White
- Enrique Carrazana
Institutions
- University of Hawaiʻi at Mānoa (US)
- University of Pittsburgh (US)
- University of Washington (US)
- Neurelis (United States) (US)
- Florida Atlantic University (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1002/epi.70051
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00