Plasma Phosphorylated Tau 217 Cutoffs for Amyloid Pathology and Kidney Function, Body Mass Index, and Anemia
This study found that both the optimal cutoff and the double-cutoff strategy outperformed the standard single cutoff, each showing distinct strengths across subgroups. These findings support biologically informed thresholds to improve diagnostic accuracy and cost efficiency when implementing plasma p-tau217.
Authors
- K. Blennow
- Philip B. Verghese (ORCID: https://orcid.org/0000-0003-4793-564X)
- Young Noh (ORCID: https://orcid.org/0000-0002-9633-3314)
- Hyemin Jang (ORCID: https://orcid.org/0000-0001-8040-5371)
- B. C. Kim
- Jung‐Ah Lee (ORCID: https://orcid.org/0000-0003-0678-5956)
- Yuna Gu (ORCID: https://orcid.org/0009-0007-3200-3977)
- E. Lee
- Fernando González-Ortiz
- Jee Hyang Jeong (ORCID: https://orcid.org/0000-0001-7945-6956)
- Ki Young Shin (ORCID: https://orcid.org/0000-0002-9847-1032)
- Jae‐Joong Kim (ORCID: https://orcid.org/0000-0002-2714-2282)
- Jong Hun Kim (ORCID: https://orcid.org/0000-0003-3830-650X)
- Yu Hyun Park (ORCID: https://orcid.org/0000-0002-6409-3037)
- Hong-Hee Won
- Joel B. Braunstein (ORCID: https://orcid.org/0000-0002-1155-0206)
- Hong-Hee Won
- Ko Woon Kim (ORCID: https://orcid.org/0000-0002-4564-9714)
- Haesook Bok
- Eun Hye Lee (ORCID: https://orcid.org/0000-0002-4206-6214)
- Chihun Kim (ORCID: https://orcid.org/0000-0003-2871-2344)
- S. Peter Kim
- Jong Hun Kim (ORCID: https://orcid.org/0000-0002-2594-1048)
- Dong Hyun Lee
- Hanna Cho (ORCID: https://orcid.org/0000-0002-5339-2541)
- Seonghyeon Kim (ORCID: https://orcid.org/0000-0002-3143-2194)
- Junpyo Kim
- Yejoo Choi
- Daeun Shin (ORCID: https://orcid.org/0000-0003-4834-1026)
- Hang-Rai Kim
- Y. Ha
- Changsik Yoon
- Na-Yeon Jung
- YoungJi Ha
- SungHui Eom
- Tim West
- Hae-Eun Shin
- Jihwan Yun (ORCID: https://orcid.org/0009-0000-4084-7327)
- Geon Ha Kim
- Yeo Jin Kim
- Jaeho Kim
- Jae-Won Jang
- H. Zetterberg
- Jin San Lee
- Juhee Chin
- Sang Won Seo
- Tak-Kyeong Lee
- Youngju Kim
- Sung Hoon Kang
- Hee Jin Kim
- Dong Young Lee
- Jun-Kyu Choi
- Bo Kyoung Cheon
- Han Na Lee
- Minyoung Cho
- Jisung Jang
- Jinkyu Seo
- Nicholas J. Ashton
- Min Young Chun
- Matthew R. Meyer
- K-ROAD Study Groups
- Do kyung Lee
- Yeongshin Kim
- Beomsu Kim
- Seunghee Na
- Giijung Jung
- Hongki Ham
- Sun-Ho Han
- Min Soo Byun
- Duk L. Na
- Dahyun Yi
- So Young Moon
- Kyunghun Kang
Institutions
- Ulsan College (KR)
- University of Science and Technology of China (CN)
- Kangwon National University (KR)
- King's College London (GB)
- Yonsei University (KR)
- Severance Hospital (KR)
- Korea University Medical Center (KR)
- Stavanger University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Asan Medical Center (KR)
- Samsung Medical Center (KR)
- Centre for Mental Health (GB)
- Kyung Hee University (KR)
- Sorbonne Université (FR)
- University of Ulsan (KR)
- Chonnam National University Hospital (KR)
- C2N Diagnostics (United States) (US)
- Inje University Haeundae Paik Hospital (KR)
- Pitié-Salpêtrière Hospital (FR)
- Dr Youth Clinic (KR)
- UK Dementia Research Institute (GB)
- Kangdong Sacred Heart Hospital (KR)
- Pusan National University Yangsan Hospital (KR)
- Hallym University Dongtan Sacred Heart Hospital (KR)
- Center for the Study of Community Colleges (US)
- Institut du Cerveau (FR)
- Yonsei University Health System (KR)
- University College London (GB)
- Jeonbuk National University (KR)
- Sungkyunkwan University (KR)
- University of Gothenburg (SE)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1001/jamaneurol.2025.5530
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- University of Wisconsin-Madison
- Demensförbundet
- National Institute for Health and Care Research
- King's College London
- University College London
- National Research Foundation
- Chonnam National University
- Kangwon National University
- Pusan National University
- University of Ulsan
- Hallym University
- Inje University
- Sungkyunkwan University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Sahlgrenska Universitetssjukhuset
- Göteborgs Universitet
- University of Science and Technology of China
- Ministry of SMEs and Startups
- Ministry of Science and ICT, South Korea
- Jeonbuk National University
- UK Dementia Research Institute
- Sorbonne Université
- Fondation pour la Recherche sur Alzheimer
- Samsung
- School of Medicine and Public Health, University of Wisconsin-Madison
- Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Korea National Institute of Health
- Sahlgrenska Akademin
- Institute for Information and Communications Technology Promotion
- School of Life Sciences and Biotechnology Division of Life Sciences, Korea University