Circulating monocytes pre-disposed to form atherogenic foam cells are characterised by distinct transcriptional changes in people with HIV
Our findings indicate that monocytes from PWH without elevated traditional cardiovascular risk factors exhibit significant transcriptional changes which are associated with heightened atherosclerosis-promoting activity.
Authors
- M. Brunton-O’Sullivan (ORCID: https://orcid.org/0000-0001-5190-5086)
- Janine M. Trevillyan (ORCID: https://orcid.org/0000-0002-8660-5558)
- Thomas A. Angelovich (ORCID: https://orcid.org/0000-0003-2069-0451)
- Jennifer C. Boer (ORCID: https://orcid.org/0000-0002-7053-0627)
- Magdalena Plebanski (ORCID: https://orcid.org/0000-0001-6889-3667)
- Jennifer F. Hoy
- Anna C. Hearps
Institutions
- Burnet Institute (AU)
- The Alfred Hospital (AU)
- Monash Alfred Psychiatry Research centre (AU)
- Austin Health (AU)
- Victoria University (AU)
- RMIT University (AU)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2026.120658
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Burnet Institute
- Medical Research Council
- National Health and Medical Research Council