Comprehensive evaluation of the anti-inflammatory potential of Cucurbita maxima leaf extract: LC–MS phytochemical profiling coupled with in vitro, in vivo, and in silico approaches
These findings support the traditional use of C. maxima leaves in folk medicine for the management of inflammation-related conditions, fever, and associated oxidative stress. Further isolation of the key active constituents and clinical evaluation are recommended to confirm their therapeutic efficacy.
Authors
- Housseyn Chaoua
- Stefanıa Garzoli (ORCID: https://orcid.org/0000-0001-8535-0533)
- Mohammed Larbi Benamor (ORCID: https://orcid.org/0000-0002-6972-4221)
- Yahia Bekkar (ORCID: https://orcid.org/0000-0001-5816-2043)
- Lazhar Bechki
- Aicha Adaika
- Hammadi Maroua
- Salah Neghmouche Nacer
- Touhami Lanez
- Elhafnaoui Lanez
- Ouafa Boudebia
Institutions
- University of Ouargla (DZ)
- Centre Hospitalo-Universitaire Bab El Oued (DZ)
- University of Eloued (DZ)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1016/j.jep.2026.121267
- Primary Topic
- Advances in Cucurbitaceae Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00