Hypermethylation-mediated silencing of RASD1 drives multiple myeloma pathogenesis

RASD1 is frequently silenced in MM through promoter hypermethylation. This epigenetic inactivation is associated with adverse clinical features and enhanced cell survival, supporting a tumor suppressor role for RASD1 in MM pathogenesis.

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Publication Details

Journal
Blood Research
Published
2026-02-02
DOI
https://doi.org/10.1007/s44313-026-00125-6
Primary Topic
Epigenetics and DNA Methylation
Type
article
Field-Weighted Citation Impact
0.00
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article

Hypermethylation-mediated silencing of RASD1 drives multiple myeloma pathogenesis

Chenfeng Yi, Yonghuai Feng, Jiajia Zhang
Blood Research
Epigenetics and DNA Methylation
article

Hypermethylation-mediated silencing of RASD1 drives multiple myeloma pathogenesis

Chenfeng Yi, Yonghuai Feng, Jiajia Zhang
article en

Abstract

RASD1 is frequently silenced in MM through promoter hypermethylation. This epigenetic inactivation is associated with adverse clinical features and enhanced cell survival, supporting a tumor suppressor role for RASD1 in MM pathogenesis.

Blood ResearchVol. 61(1)
Zunyi Medical University (CN), Dongguan People’s Hospital (CN), Jinhua University of Vocational Technology (CN), Jinhua Central Hospital (CN), Affiliated Hospital of Zunyi Medical College (CN)
Reduced inequalities
Openalex Percentile: Top 70%
Epigenetics and DNA Methylation
DOIOpen Access PDFOpenAlex
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