The association between long-term opioid therapy and composite infection-related dental outcomes
he observed positive association between LTOT and CIDO in this large VA sample may inform patient-provider discussions and decision-making around use of LTOT. High CIDO rates among patients with full VA dental coverage may reflect their unique vulnerability to dental infection associated with service-related dental or disabling conditions. Limitations include risk for ascertainment bias, unclear generalizability to a broader clinical population, and the potential for residual confounding.
Authors
- Gretchen Gibson (ORCID: https://orcid.org/0000-0001-9345-8552)
- M. Marianne Jurasic (ORCID: https://orcid.org/0000-0002-8179-1443)
- Kirsha S. Gordon (ORCID: https://orcid.org/0000-0002-4925-1914)
- Declan T. Barry (ORCID: https://orcid.org/0000-0001-6697-5220)
- James D Dziura (ORCID: https://orcid.org/0000-0001-8953-6183)
- Anne C. Black (ORCID: https://orcid.org/0000-0003-0295-7351)
- Michelle Hamilton
- William C. Becker
- Katie Suda
- Melissa Skanderson
- E. Jennifer Edelman
- Brandon D.L. Marshall
- Yu Li
- Stephen Crystal
Institutions
- Rutgers, The State University of New Jersey (US)
- Boston University (US)
- University of Pittsburgh (US)
- Brown University (US)
- VA Office of Research and Development (US)
- Yale University (US)
- VA Connecticut Healthcare System (US)
- VA New England Healthcare System (US)
- APT Foundation (US)
- Veterans Health Care System of the Ozarks (US)
- Yale New Haven Health System (US)
- VA Pittsburgh Healthcare System (US)
- Washington DC VA Medical Center (US)
- University of Missouri–Kansas City (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1371/journal.pone.0341361
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00