Clinical Signs Associated With Mortality and Sepsis in Young Infants

All current WHO IMCI clinical signs were significantly associated with mortality or culture-confirmed sepsis. Several signs not in IMCI were identified that may improve identification of life-threatening illness in young infants in resource-limited settings where clinical sign algorithms are the primary diagnostic tool.

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Publication Details

Journal
JAMA Pediatrics
Published
2026-02-02
DOI
https://doi.org/10.1001/jamapediatrics.2025.5967
Primary Topic
Neonatal and Maternal Infections
Type
article
Field-Weighted Citation Impact
0.00
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article

Clinical Signs Associated With Mortality and Sepsis in Young Infants

Anne CC Lee, Yasir Shafiq, Sophie Driker, Sitarah Mathias et al.
JAMA Pediatrics
Neonatal and Maternal Infections
article

Clinical Signs Associated With Mortality and Sepsis in Young Infants

Anne CC Lee, Yasir Shafiq, Sophie Driker, Sitarah Mathias, Chris A Rees, Alastair Fung, Anum S. Hussaini, Suci Ardini Widyaningsih, Jana Adnan, Naomi Schmeck, Amber Hoey, Tessa Kehoe, Rishi P. Mediratta, Carrie G. Wade, Krysten North, Yumin Kim
article en

Abstract

All current WHO IMCI clinical signs were significantly associated with mortality or culture-confirmed sepsis. Several signs not in IMCI were identified that may improve identification of life-threatening illness in young infants in resource-limited settings where clinical sign algorithms are the primary diagnostic tool.

JAMA Pediatrics
Bryn Mawr College (US), Aga Khan University (PK), Brigham and Women's Hospital (US), Boston Children's Hospital (US), Harvard University (US), Emory University (US), Brown University (US), Hospital for Sick Children (CA), Boston Public Library (US), Massachusetts General Hospital (US), Stanford Medicine (US), SickKids Foundation (CA), Field Foundation (US)
Good health and well-being
Openalex Percentile: Top 71%
Neonatal and Maternal Infections
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Clinical Signs Associated With Mortality and Sepsis in Young Infants — Anne CC Lee, Yasir Shafiq, et al. · JAMA Pediatrics (2026) | TGRS Research Map | TGRS