Association between chronic stress-related amygdala metabolic activity and distant metastasis in colorectal cancer

Elevated amygdala metabolic activity on pre-treatment ¹<sup>8</sup>F-FDG PET/CT, a surrogate marker of chronic stress, was independently associated with distant metastasis in CRC. AmygA might serve as a novel imaging biomarker for risk stratification and offer insight into stress-related neural mechanisms underlying metastatic progression.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2026-02-03
DOI
https://doi.org/10.3389/fendo.2026.1747732
Primary Topic
Cancer, Stress, Anesthesia, and Immune Response
Type
article
Field-Weighted Citation Impact
0.00

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article

Association between chronic stress-related amygdala metabolic activity and distant metastasis in colorectal cancer

Chanmin Joung, Sejin Ha, Sungeun Kim, Kisoo Pahk et al.
Frontiers in Endocrinology
Cancer, Stress, Anesthesia, and Immune Response
article

Association between chronic stress-related amygdala metabolic activity and distant metastasis in colorectal cancer

Chanmin Joung, Sejin Ha, Sungeun Kim, Kisoo Pahk, Hyun Joo Kim
article en

Abstract

Elevated amygdala metabolic activity on pre-treatment ¹<sup>8</sup>F-FDG PET/CT, a surrogate marker of chronic stress, was independently associated with distant metastasis in CRC. AmygA might serve as a novel imaging biomarker for risk stratification and offer insight into stress-related neural mechanisms underlying metastatic progression.

Frontiers in EndocrinologyVol. 17
Korea University (KR), The Catholic University of Korea Uijeongbu St. Mary's Hospital (KR), The University of Texas Southwestern Medical Center (US)
Korea University, Korea Health Industry Development Institute, Daewoong Pharmaceutical Company, Korea University Anam Hospital
Good health and well-being
Openalex Percentile: Top 70%
Cancer, Stress, Anesthesia, and Immune Response
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