Infliximab and Upadacitinib Demonstrate Superior Early Onset of Efficacy in Biologic-Naïve Ulcerative Colitis With Severe Endoscopic Disease

Among biologic-naïve UC patients with severe endoscopic disease, infliximab and upadacitinib had the highest rates of week 2 and postinduction PRO-2 response. Baseline disease activity may help to better inform treatment choices.

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Publication Details

Journal
The American Journal of Gastroenterology
Published
2026-02-02
DOI
https://doi.org/10.14309/ajg.0000000000003940
Primary Topic
Inflammatory Bowel Disease
Type
article
Field-Weighted Citation Impact
0.00
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article

Infliximab and Upadacitinib Demonstrate Superior Early Onset of Efficacy in Biologic-Naïve Ulcerative Colitis With Severe Endoscopic Disease

N Narula, Emily CL Wong, C Ma, John K. Marshall et al.
The American Journal of Gastroenterology
Inflammatory Bowel Disease
article

Infliximab and Upadacitinib Demonstrate Superior Early Onset of Efficacy in Biologic-Naïve Ulcerative Colitis With Severe Endoscopic Disease

N Narula, Emily CL Wong, C Ma, John K. Marshall, Walter Reinisch, Vipul Jairath, Parambir S. Dulai
article en

Abstract

Among biologic-naïve UC patients with severe endoscopic disease, infliximab and upadacitinib had the highest rates of week 2 and postinduction PRO-2 response. Baseline disease activity may help to better inform treatment choices.

The American Journal of Gastroenterology
Northwestern University (US), Western University (CA), University of Calgary (CA), Population Health Research Institute (CA), Medical University of Vienna (AT), McMaster University (CA)
Good health and well-being
Openalex Percentile: Top 65%
Inflammatory Bowel Disease
DOISourceOpenAlex
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