Synergistic immune protection of exosomal T-cell epitope vaccine and antibody-inducing vaccine against SARS-CoV-2 in highly humanized mice

This study, for the first time, demonstrates the synergistic humoral and cellular immune responses and protective efficacy induced by the combined immunization of exosomal T-cell epitope vaccine and antibody-inducing vaccine, and provides preclinical evidence from highly humanized mice for optimizing next-generation SARS-CoV-2 vaccine protocols.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-02-03
DOI
https://doi.org/10.3389/fimmu.2026.1729444
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
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article

Synergistic immune protection of exosomal T-cell epitope vaccine and antibody-inducing vaccine against SARS-CoV-2 in highly humanized mice

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Frontiers in Immunology
SARS-CoV-2 and COVID-19 Research
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Synergistic immune protection of exosomal T-cell epitope vaccine and antibody-inducing vaccine against SARS-CoV-2 in highly humanized mice

Anran Shen, Min Li, Yandan Wu, Linli Lv, Guangyu Zhao, Taotao Tang, Qi Yin, Xuelian Han, Yuan Wang, Jiejie Zhang, Yue Zhang, Yu Zhao, Suyue Zhu
article en

Abstract

This study, for the first time, demonstrates the synergistic humoral and cellular immune responses and protective efficacy induced by the combined immunization of exosomal T-cell epitope vaccine and antibody-inducing vaccine, and provides preclinical evidence from highly humanized mice for optimizing next-generation SARS-CoV-2 vaccine protocols.

Frontiers in ImmunologyVol. 17
Military Medical Academy (RS), Academy of Military Medical Sciences (CN), Southeast University (BD), Zhongda Hospital Southeast University (CN), Military Medical Academy (EG)
Good health and well-being
Openalex Percentile: Top 67%
SARS-CoV-2 and COVID-19 Research
DOIOpen Access PDFOpenAlex
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