STAT1 transcriptionally activates CXCL13 to promote cell inflammation and proliferation and inhibit cell apoptosis in rheumatoid arthritis fibroblast-like synoviocytes
STAT1 transcriptionally activated CXCL13 to enhance inflammation, promote proliferation, and suppress apoptosis in RA-FLS. These findings highlight the STAT1/CXCL13 axis as a potential therapeutic target for modulating synovial hyperplasia and inflammation in RA.
Authors
- Liguo Yin
- Mei Wang
- Xia Wang
- Naiwen Hu
- Na Zhao
Institutions
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1186/s13018-026-06699-2
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00