Intradiscal linezolid (PP353) treatment for chronic low back pain associated with Modic change type 1: an international, first-in-human, randomised, sham procedure-controlled, double-blind, phase 1b clinical trial
Persica Pharmaceuticals Ltd funded the trial and was responsible for the conceptualisation, overall design, collation of data, decision to publish and the first draft of the manuscript.
Authors
- Ian Ratcliffe
- Aprajay Golash
- Simon Klaasen
- Andy Whelan
- Nigel Gilchrist (ORCID: https://orcid.org/0009-0003-8907-8129)
- Lloyd G. Czaplewski (ORCID: https://orcid.org/0000-0002-8263-0190)
- Shane Smith (ORCID: https://orcid.org/0000-0001-5612-6807)
- Neeraj Purohit
- Judith Paredes Sanchez (ORCID: https://orcid.org/0009-0008-2788-8958)
- John Titterington
- Emily Wood (ORCID: https://orcid.org/0000-0002-1466-5615)
- Byron J. Oram
- Seema Jaitly
- Michelle Kümin (ORCID: https://orcid.org/0000-0003-4618-6528)
- Hilory Ricketts
- Kristian Stahl Otte
- A. Horcajadas (ORCID: https://orcid.org/0000-0003-3409-2671)
- Russell Outlaw
- Vaughan Reed (ORCID: https://orcid.org/0000-0001-6552-1710)
- Otis Rimmer
- Lisa Speight
- Helen Linley
- Rajat Chowdhury
- Charlie Brindley
- Ingrid Franklin
- Paul J. Cummings
- Carlos Tornero Tornero
- Kris Dazell
- Michael R. Lassen
- Eulene Gooden
- Graham Scott
- Javier DeAndres
- Jonas Walborn
- Parag Desai
- Jacquline Bramley
- Matthew Scarborough
- Graham Blakey
- Deirdre Thompson
- Cathy Price
- Claire Scarborough
- Kausik Mukherjee
- Ganesan Baranidharan
- Sarah Guest
- Sunette Morre
- Prof Mikael Boesen
- Elizabeth McGough
- Duncan McHale
- Yaron Berkowitz
- Elizabeth Coates
- Pheobe Wamban
- Sheela Black
- Conrad Stroud
- M'Lissa Hall
- Philippe Rigoard
- Jeremy Fairbank
- Sashin Ahuja
Institutions
- Lancashire Teaching Hospitals NHS Foundation Trust (GB)
- Cardiff and Vale University Health Board (GB)
- University of Kent (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Hospital Universitario La Paz (ES)
- Isle of Wight NHS Trust (GB)
- Nuffield Orthopaedic Centre (GB)
- Gentofte Hospital (DK)
- Complejo Hospitalario Universitario de Granada (ES)
- Christchurch Clinical Studies Trust (NZ)
- Richmond upon Thames College (GB)
Publication Details
- Journal
- EClinicalMedicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.eclinm.2026.103764
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 36.00