Real-world effectiveness and safety of psychedelic-assisted psychotherapy: Outcomes from a large-scale compassionate use cohort in Switzerland

In this compassionate-use real-world cohort, a first fully-active dose PAP session with LSD or psilocybin was well tolerated and associated with significant improvements in depressive and anxiety symptoms. These findings support the feasibility and effectiveness of PAP in specialised routine care.

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Publication Details

Journal
Psychiatry Research
Published
2026-02-02
DOI
https://doi.org/10.1016/j.psychres.2026.116992
Primary Topic
Psychedelics and Drug Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Real-world effectiveness and safety of psychedelic-assisted psychotherapy: Outcomes from a large-scale compassionate use cohort in Switzerland

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Real-world effectiveness and safety of psychedelic-assisted psychotherapy: Outcomes from a large-scale compassionate use cohort in Switzerland

F. Seragnoli, T. Aboulafia-Brakha, R. Iuga, L. Penzenstadler, C. Amberger, L. Szczesniak, C. Mabilais, G. Thorens, M. Sabé, L. Furtado, J-F Briefer, A. Buchard, S. Alaux, D. Zullino
article en

Abstract

In this compassionate-use real-world cohort, a first fully-active dose PAP session with LSD or psilocybin was well tolerated and associated with significant improvements in depressive and anxiety symptoms. These findings support the feasibility and effectiveness of PAP in specialised routine care.

Psychiatry ResearchVol. 358
University of Geneva (CH), University Hospital of Geneva (CH), Geneva College (US)
Good health and well-being
Openalex Percentile: Top 71%
Psychedelics and Drug Studies
DOIOpen Access PDFOpenAlex
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