Migraine-induced cochlear injury triggers ZBP1-mediated PANoptosis via CGRP signaling
We demonstrated OHCs as the key targets in CM-induced, CGRP-mediated peripheral hearing impairment. CGRP exerts its pathogenic role by triggering a cascade of intracellular stress and inflammatory pathways, ultimately leading to cell death. These findings provide a phenotypic basis for a subtype of migraine-induced hearing loss, paving the way for auditory protection strategies.
Authors
- Wandi Xu (ORCID: https://orcid.org/0000-0002-1457-8677)
- Ziyu Zhai
- Sulin Zhang (ORCID: https://orcid.org/0000-0002-3609-6804)
- Ni Zhai
- Xixi Yu
- E. Tian
- Shun Zhou
- Yisheng Lu
- Zhaoqi Guo (ORCID: https://orcid.org/0000-0002-6516-3295)
- Jingyu Chen
- Xin Ma
- Zhanghong Zhou (ORCID: https://orcid.org/0000-0002-8300-4079)
- Yixu Wang
- Xin Zhang
Institutions
- Shihezi University (CN)
- Peking University (CN)
- Peking University People's Hospital (CN)
- Wuhan Union Hospital (CN)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1186/s10194-026-02286-2
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00