Intra-articular injection of autologous tolerogenic dendritic cells modifies the synovial immune landscape in rheumatoid and inflammatory arthritis
The tolDC-induced increase in synovial Myeloid MerTK<sup>High</sup> cells may have local immune modulatory effects and provide promising evidence for an effect of tolDC treatment on the synovial immune landscape.
Authors
- Ben Millar
- Arthur G. Pratt (ORCID: https://orcid.org/0000-0002-9909-8209)
- Andrew Filby (ORCID: https://orcid.org/0000-0001-9078-4360)
- Ioana Nicorescu (ORCID: https://orcid.org/0000-0002-5043-3280)
- Domenico Somma (ORCID: https://orcid.org/0000-0003-2486-7250)
- Kenneth S. Rankin (ORCID: https://orcid.org/0000-0001-6302-0269)
- Julie Diboll
- Jack Harrison
- Andrew Filer
- Amanda Thomson
- Amy E. Anderson
- Mariola Kurowska-Stolarska
- Catharien M.U. Hilkens
- Luke J. Jones
- David McDonald
- George Merces
- John D. Isaacs
Institutions
- Arthritis UK (GB)
- NIHR Newcastle Biomedical Research Centre (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.ard.2026.01.004
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00