Impact of ECOG performance status 2 participants on outcomes of pivotal cancer clinical trials: a meta-analysis and meta-regression

Although PS 2 participants showed a greater propensity to serious toxicity, no significant differences in efficacy outcomes were observed compared with those with PS ≤1. Our results support the inclusion of PS 2 participants in clinical trials, as their exclusion limits the generalizability of results.

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Publication Details

Journal
ESMO Open
Published
2026-02-01
DOI
https://doi.org/10.1016/j.esmoop.2026.106065
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
0.00
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article

Impact of ECOG performance status 2 participants on outcomes of pivotal cancer clinical trials: a meta-analysis and meta-regression

J. Gulley, D. Giannarelli, G.M. Iannantuono, A. Vitale et al.
ESMO Open
Lung Cancer Treatments and Mutations
article

Impact of ECOG performance status 2 participants on outcomes of pivotal cancer clinical trials: a meta-analysis and meta-regression

J. Gulley, D. Giannarelli, G.M. Iannantuono, A. Vitale, P. Navarra, T. Giovagnoli, B. Gyawali, S. Sganga, F. Lo Bianco, G. Daniele, L. Mastrantoni, M. Filetti, E. Giudice, E. Bria, A. Spinazzola, C.S. Floudas
article en

Abstract

Although PS 2 participants showed a greater propensity to serious toxicity, no significant differences in efficacy outcomes were observed compared with those with PS ≤1. Our results support the inclusion of PS 2 participants in clinical trials, as their exclusion limits the generalizability of results.

ESMO OpenVol. 11(2)
Università Cattolica del Sacro Cuore (IT), National Institutes of Health (US), Humanitas University (IT), Queen's University (CA), Agostino Gemelli University Polyclinic (IT), National Cancer Institute (US), Center for Cancer Research (US)
Reduced inequalities
Openalex Percentile: Top 70%
Lung Cancer Treatments and Mutations
DOIOpen Access PDFOpenAlex
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