Genome-Wide Association Study Identifies Genetic Loci for Antibody Response to SARS-CoV-2 Vaccines in Patients With Systemic Autoimmune Diseases and Healthy Individuals
This study highlights both MHC and non-MHC genetic contributions to SARS-CoV-2 vaccine responses and suggests these effects are consistent across patients with SADs and healthy individuals, supporting standard vaccination strategies for individuals with systemic autoimmune conditions.
Authors
- Sophie Kelly (ORCID: https://orcid.org/0000-0001-8350-3671)
- Sarthak Gupta (ORCID: https://orcid.org/0000-0001-8255-3554)
- Mariana J. Kaplan (ORCID: https://orcid.org/0000-0003-2968-0815)
- Dillon Claybaugh (ORCID: https://orcid.org/0009-0001-4301-8601)
- Andrew Lee Mammen (ORCID: https://orcid.org/0000-0003-3732-3252)
- Vibha Vij (ORCID: https://orcid.org/0000-0002-1411-0257)
- Nancy Spencer (ORCID: https://orcid.org/0000-0002-8300-3287)
- Elaine Poncio
- Heather Kalish (ORCID: https://orcid.org/0000-0002-4848-2067)
- Alice Fike (ORCID: https://orcid.org/0000-0003-2597-1981)
- Jun Chu
- Kaitlin A. Quinn (ORCID: https://orcid.org/0000-0002-5794-194X)
- Michael A. Davis (ORCID: https://orcid.org/0000-0002-5406-4128)
- Lilian Howard
- Eileen Pelayo
- Meryl Waldman (ORCID: https://orcid.org/0000-0001-8698-0502)
- Peter C. Grayson (ORCID: https://orcid.org/0000-0002-8269-9438)
- Adam I. Schiffenbauer (ORCID: https://orcid.org/0000-0001-9964-9966)
- Eduardo Patino Martinez
- Julie Onyechi
- Martha Sully
- Sarah Porche
- Iago Pinal-Fernandez
- Zerai Manna
- Blake M. Warner
- Margaret E. Beach
- Lisa Mirabello
- Yanira Ruiz-Perdomo
- Laura B. Lewandowski
- Luis M. Franco
- Lisa G. Rider
- Yenealem Temesgen-Oyelakin
- Stephen J. Chanock
- Rita Volochayev
Institutions
- National Institutes of Health (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Kyung Hee University (KR)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (US)
- National Institute of Biomedical Imaging and Bioengineering (US)
- National Institute of Dental and Craniofacial Research (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Office of the Director (US)
- National Institute of Nursing Research (US)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- Department of Health and Human Services (US)
Publication Details
- Journal
- The Journal of Rheumatology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.3899/jrheum.2025-0770
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- University of Oxford
- Kyung Hee University
- National Institutes of Health
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases