Characterizing early behavioral and social–emotional problems in young children with <scp> <i>SCN1A</i> </scp> + Dravet syndrome: Findings from the <scp>ENVISION</scp> prospective natural history study
We found that behavioral and social-emotional problems are inherent components of DS that present in toddlerhood and worsen throughout early childhood. This highlights the need to diagnose and manage these issues early. Targeted therapy may alleviate the wide-ranging morbidities that are intrinsic to DS, including the social-emotional and behavior problems that frequently emerge.
Authors
- Norman Huang
- Mary Wojnaroski (ORCID: https://orcid.org/0009-0006-5595-0419)
- Matt Lallas
- Andreas Brunklaus (ORCID: https://orcid.org/0000-0002-7728-6903)
- Sarah Christensen (ORCID: https://orcid.org/0000-0001-5790-6266)
- Kelly G. Knupp (ORCID: https://orcid.org/0000-0002-1967-0827)
- Deborah Holder
- Maria Candida Vila (ORCID: https://orcid.org/0000-0003-4593-5822)
- Anup D. Patel
- J. P. Sullivan (ORCID: https://orcid.org/0000-0002-9067-1531)
- J. W. Wheless
- Jacqueline S. Gofshteyn (ORCID: https://orcid.org/0000-0003-3354-6176)
- Dennis J. Dlugos
- Dennis Lal (ORCID: https://orcid.org/0000-0003-2591-432X)
- Madison Berl
- Linda C Laux
- M. Scott Perry
- Emma S. James
- Steven Phillips
- Ingrid E. Scheffer
- Salvador Rico
- Sameer M. Zuberi
- Rebecca Shaffer
- Elaine Wirrell
- Colin Roberts
Institutions
- Northwestern University (US)
- Cincinnati Children's Hospital Medical Center (US)
- Lurie Children's Hospital (US)
- Nationwide Children's Hospital (US)
- Royal Children's Hospital (AU)
- Hackensack University Medical Center (US)
- MultiCare Health System (US)
- Mayo Clinic (US)
- Children's Hospital of Philadelphia (US)
- Children's National (US)
- Children's Hospital of Los Angeles (US)
- University of California, San Francisco (US)
- Royal Hospital for Children (GB)
- Hospital de Sant Pau (ES)
- Cleveland Clinic Lerner College of Medicine (US)
- Rapt Therapeutics (United States) (US)
- Cook Children's Medical Center (US)
- Children's Hospital Colorado (US)
- NorthEast Regional Epilepsy Group (US)
- Miami Children's Hospital (US)
- Hackensack Meridian Health (US)
- Murdoch Children's Research Institute (AU)
- Doernbecher Children's Hospital (US)
- Le Bonheur Children's Hospital (US)
- Austin Health (AU)
- University of Colorado Denver (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1002/epi.70127
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Autism Speaks
- Patient-Centered Outcomes Research Institute
- Dravet Syndrome Foundation
- Pediatric Epilepsy Research Foundation
- Jazz Pharmaceuticals
- Dravet Syndrome UK
- Zogenix
- LivaNova
- GW Pharmaceuticals
- Neurocrine Biosciences
- Amicus Therapeutics
- Marinus Pharmaceuticals
- Upsher-Smith
- Epilepsy Research UK
- University of Glasgow
- Eisai
- Servier
- H. Lundbeck A/S
- Epilepsiatutkimussäätiö
- National Institutes of Health
- University of California, San Francisco
- Greenwich Biosciences
- UCB Pharma