Helicobacter pylori contributes to GC progression, possibly via the MSTRG.10627.1/miR-142-5p/ADAMTS5 pathway
The expression of ADAMTS5 was down-regulated by <i>H. pylori</i> through regulating a probable pathway (MSTRG.10627.1-miR-142-5p-ADAMTS5). Moreover, down-regulated ADAMTS5 induced PI3K protein, up-regulated phosphorylated AKT protein, and down-regulated p53, which plays an important role in the induction of GC.
Authors
- Nianli Zhang (ORCID: https://orcid.org/0000-0002-8008-9636)
- Yi Wu (ORCID: https://orcid.org/0000-0002-8813-6687)
- Nianhua Zhang
- Jianwei Xiang
- Zhipeng Yin
- Gang Lv
- Pengbo Guo
- Yinghui Zhao
Institutions
- Fujian Medical University (CN)
- Shandong University (CN)
- Weifang People's Hospital (CN)
- Shandong Provincial Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-02-02
- DOI
- https://doi.org/10.3389/fmicb.2025.1686246
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00