Downhill Running Blocks the Mitophagic Flux and Autophagosome-Lysosome Fusion in Rat Soleus Muscle
A bout of downhill running may block mitophagic flux by impairing mitophagosome-lysosome fusion, which is accompanied by increased recruitment of STX17 and SNAP29 to autophagosome and reduced co-localizations of STX17 and SNAP29 with lysosomal VAMP8.
Authors
- Tianai Yang
- Hao Deng (ORCID: https://orcid.org/0000-0002-6417-6406)
- Duo Zhang (ORCID: https://orcid.org/0000-0002-0092-9042)
- Huayu Shang
- Mengyu Li
- Zhi Xia
- Ranggui Ma
- Shiqiao Zheng
Institutions
- Wenzhou University (CN)
- Chengdu Sport University (CN)
- Chongqing University of Education (CN)
- Beijing Sport University (CN)
Publication Details
- Journal
- Medicine & Science in Sports & Exercise
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1249/mss.0000000000003955
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00