Development and characterization of microfluidic chips with thermal properties employing magnetic hyperthermia

There are many fields, such as microfluidics and Organ-on-a-chip technologies, where an optimal setting and control of temperature is necessary. These fields are reaching the forefront of personalised medicine, thus requiring developing more complex systems to adequately mimic any biological condition. On this work we propose the design and fabrication of a microfluidic chip mixing Polydimethylsiloxane (PDMS) and magnetic nanoparticles (MNPs) to obtain a device whose temperature could be adjusted by means of magnetic hyperthermia. Characterization of the device was performed with confocal microscopy and microcomputed tomography (micro-CT). Magnetic hyperthermia was employed to estimate the heating curve of the devices and Computational Fluid Dynamics (CFD) simulations enabled to analyse the heat distribution within the device when introducing flow.