Low-frequency repetitive transcranial magnetic stimulation attenuates visceral pain in IBS with diarrhoea via inhibition of the medial prefrontal cortex
Hyperexcitability of the mPFC drives chronic visceral pain in patients with IBS-D and lf-rTMS provides analgesia by suppressing this hyperactivity, offering a novel, mechanism-based neuromodulation strategy for IBS-D treatment.
Authors
- Shufen Hu (ORCID: https://orcid.org/0000-0002-5912-5532)
- Y H Li (ORCID: https://orcid.org/0009-0007-8694-5150)
- Weiming Zhao (ORCID: https://orcid.org/0000-0001-8977-0519)
- Qian Sun (ORCID: https://orcid.org/0000-0002-0297-5376)
- Shu-Man Jia
- Rui-Xia Weng
- Fu-Chao Zhang
- Chen-Hao Zhang (ORCID: https://orcid.org/0009-0002-2483-5988)
- Chun-Tao Ma
- Rui Li
- Wei Lin
- You-Jia Yu
- Guang-Yin Xu
Institutions
- Suzhou Polytechnic Institute of Agriculture (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- The Fifth People’s Hospital of Suzhou (CN)
Publication Details
- Journal
- Gut
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1136/gutjnl-2025-337612
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- National Key Research and Development Program of China