Bacillus Calmette-Guérin Plus Mitomycin Versus Bacillus Calmette-Guérin Alone for Bacillus Calmette-Guérin–naïve Non–muscle-invasive Bladder Cancer: A Randomised Phase 3 Trial (ANZUP 1301)
BCG + MM was not proved superior to BCG alone, but required 39% fewer doses of BCG and fewer treatment discontinuations. These findings support consideration of BCG + MM as a pragmatic alternative to BCG alone, which could mitigate the global shortage of BCG.
Authors
- Leanna Cheung
- Cynthia Hawks (ORCID: https://orcid.org/0000-0001-7848-9537)
- Shomik Sengupta
- Emma K. Beardsley
- Patricia Bastick
- Gavin Marx
- Andrew Mitterdorfer (ORCID: https://orcid.org/0000-0003-3080-1012)
- Ian Byard
- Steve P. McCombie (ORCID: https://orcid.org/0000-0002-3920-994X)
- Conrad Bishop
- Jeremy Grummet (ORCID: https://orcid.org/0000-0003-4382-8169)
- Ratnesh Kumar Srivastav
- Joseph Ischia (ORCID: https://orcid.org/0000-0001-7177-3631)
- Laurence E. Krieger (ORCID: https://orcid.org/0000-0002-6894-6041)
- Alison Blatt
- William Green
- Alison Y. Zhang
- Martin R. Stockler
- Matthew Roberts
- Dickon Hayne
- Lewis Chan
- Andrew J. Martin
- Paul J. Anderson
- Manish R. Patel
- Andrew D. Redfern
- Matthew Winter
- Hayley Thomas
Institutions
- The University of Sydney (AU)
- The Royal Melbourne Hospital (AU)
- The University of Queensland (AU)
- The University of Western Australia (AU)
- Sydney Adventist Hospital (AU)
- Harry Perkins Institute of Medical Research (AU)
- Epworth Hospital (AU)
- Valley Hospital (US)
- Concord Repatriation General Hospital (AU)
- John Hunter Hospital (AU)
- Fiona Stanley Hospital (AU)
- Nepean Hospital (AU)
- Frankston Hospital (AU)
- The Alfred Hospital (AU)
- Westmead Hospital (AU)
- Cancer Australia (AU)
- Tweed Shire Council (AU)
- Eastern Health (AU)
- Footscray Hospital (AU)
- Northern Cancer Institute (AU)
- Redcliffe Hospital (AU)
- Austin Health (AU)
- National Health and Medical Research Council (AU)
- Monash University (AU)
Publication Details
- Journal
- European Urology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.eururo.2026.01.009
- Citations
- 2
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 78.29