Gut microbial signatures of advanced hepatocellular carcinoma and their potential diagnostic value
This study reveals distinct gut microbial signatures associated with advanced HCC and suggests that <i>Enterococcus</i> may serve as a potentially important microbial marker linked to disease severity. Integrating gut microbiota profiling with clinical features may offer a promising noninvasive strategy for the accurate identification of advanced HCC and provides hypothesis-generating insights for microbiome-based therapeutic interventions.
Authors
- Zhiyong Lai
- Zhongyuan Bai (ORCID: https://orcid.org/0009-0006-5574-6258)
- Y. Wang
- Chuang Liu (ORCID: https://orcid.org/0000-0003-0431-2856)
- Tiantian Zhang (ORCID: https://orcid.org/0000-0001-6664-3322)
- Zhen Yang (ORCID: https://orcid.org/0000-0003-0806-6517)
- Wentao Miao
- Yufeng Liu
- Jun Xu
- Xiang Li
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
- Shanxi Eye Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-02-02
- DOI
- https://doi.org/10.3389/fmicb.2026.1760859
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shanxi Medical University
- ShanXi Science and Technology Department
- Shanxi Provincial Education Department