DNA methylation triage of human papillomavirus-positive atypical squamous cells of undetermined significance in cervical cancer screening
The host multigene DNA methylation assay demonstrates high specificity and good sensitivity for triaging HPV-positive ASC-US women, with the potential to reduce colposcopy referrals while maintaining robust detection of high-grade lesions, particularly in those aged ≥30 years.
Authors
- Zhenghua Teng
- Fangrong Shen
- Fang Hou (ORCID: https://orcid.org/0000-0002-2463-7087)
- Ying Sha (ORCID: https://orcid.org/0000-0002-2906-0061)
- Peng Jie (ORCID: https://orcid.org/0000-0002-1481-5353)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Xiaoxiao Yang
- Jie Li
- Weiwei Xia
Institutions
- Suzuki (Japan) (JP)
- Soochow University (CN)
- Zhangjiagang First People's Hospital (CN)
- Hanzhong People's Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Obstetrics and Gynaecology
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1080/01443615.2026.2623828
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00