Genetic susceptibility to PM2.5 exposure and transcriptional responses in pediatric asthma: insights from single-cell transcriptomics
These integrative genomic and transcriptomic analyses nominate TGF-β1-SMAD/MAPK signaling as a biologically plausible axis of genetic susceptibility to PM<sub>2.5</sub> in pediatric asthma. Given the modest sample size and indirect nature of enrichment-based inference, these findings should be considered hypothesis-generating and motivate targeted functional validation.
Authors
- Cuiping Hou
- Frank Mentch (ORCID: https://orcid.org/0000-0003-4889-6961)
- Jelte Kelchtermans (ORCID: https://orcid.org/0000-0001-9186-7547)
- Sharon A. McGrath‐Morrow (ORCID: https://orcid.org/0000-0002-1576-5394)
- Huiqi Qu (ORCID: https://orcid.org/0000-0001-9317-4488)
- Hakon Hakonarson
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3389/fimmu.2026.1644537
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Children's Hospital of Philadelphia
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Mental Health
- National Institute on Drug Abuse
- National Human Genome Research Institute
- NIH Office of the Director
- National Cancer Institute
- National Institute of Neurological Disorders and Stroke
- Common Fund