Intraosseous Atypical Verrucopapillary Epithelial Proliferation with Verrucous Carcinoma Features Evolving from a Keratinizing Odontogenic Cyst: Report of an Uncommon Variant and Review of the Literature

Here, we report an uncommon case of intraosseous AVPEP with VC features developing from the epithelial lining of a keratinizing DOC. Despite their alarming histopathologic appearance, a review of the literature reveals that such lesions tend to have a favorable prognosis following complete surgical excision.

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Publication Details

Journal
Head and Neck Pathology
Published
2026-02-02
DOI
https://doi.org/10.1007/s12105-026-01890-7
Primary Topic
Oral and Maxillofacial Pathology
Type
article
Field-Weighted Citation Impact
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article

Intraosseous Atypical Verrucopapillary Epithelial Proliferation with Verrucous Carcinoma Features Evolving from a Keratinizing Odontogenic Cyst: Report of an Uncommon Variant and Review of the Literature

Kristin K. McNamara, Prokopios P. Argyris, Kristie L. Wise, John R. Kalmar
Head and Neck Pathology
Oral and Maxillofacial Pathology
article

Intraosseous Atypical Verrucopapillary Epithelial Proliferation with Verrucous Carcinoma Features Evolving from a Keratinizing Odontogenic Cyst: Report of an Uncommon Variant and Review of the Literature

Kristin K. McNamara, Prokopios P. Argyris, Kristie L. Wise, John R. Kalmar
article en

Abstract

Here, we report an uncommon case of intraosseous AVPEP with VC features developing from the epithelial lining of a keratinizing DOC. Despite their alarming histopathologic appearance, a review of the literature reveals that such lesions tend to have a favorable prognosis following complete surgical excision.

Head and Neck PathologyVol. 20(1)
OhioHealth (US), University of Chicago (US), The Ohio State University (US)
Openalex Percentile: Top 70%
Oral and Maxillofacial Pathology
DOIOpen Access PDFOpenAlex
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Intraosseous Atypical Verrucopapillary Epithelial Proliferation with Verrucous Carcinoma Features Evolving from a Keratinizing Odontogenic Cyst: Report of an Uncommon Variant and Review of the Literature — Kristin K. McNamara, Prokopios P. Argyris, et al. · Head and Neck Pathology (2026) | TGRS Research Map | TGRS