Transition‐Metal‐Free C‐1 Arylation of Isoquinolines With Arylhydrazine Salts
ABSTRACT A transition‐metal‐free synthesis of 1‐arylisoquinolines has been achieved using arylhydrazine salts as arylating reagents in the presence of K 2 CO 3 and K 2 S 2 O 8 . This protocol is metal‐free, requires no specific ligands, and is characterized by operational simplicity, reliability, mild conditions, and environmental benignity. It is thus applicable for constructing bioactive molecules containing the 1‐arylisoquinoline scaffold.
Authors
- Aibo LIU
- Rong Tan (ORCID: https://orcid.org/0000-0003-0747-5554)
- Xing Wang (ORCID: https://orcid.org/0000-0001-8762-5617)
- Ling Li (ORCID: https://orcid.org/0009-0005-2256-6333)
- Shenggang Yang (ORCID: https://orcid.org/0000-0003-3373-8741)
- Caifu Deng
- Yongdong Yang
- Cong Wang
Institutions
- Guiyang Medical University (CN)
- University of Electronic Science and Technology of China (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Chongqing Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- Journal of Heterocyclic Chemistry
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1002/jhet.70168
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00