Single cell RNA sequencing analysis and molecular biology experiments identify NAFLD-related fibroblasts and highlights seven hub genes in NAFLD
Our investigation has uncovered a distinct fibroblast population closely associated with NAFLD pathogenesis. The related genes, including CCL2, CRYAB, HSBP1, IFIT3, PSMB10, RBX1, and SPARC, with potential promoting or inhibitory roles in NAFLD pathogenesis, were subsequently identified and represented a crucial step in developing prospective clinical diagnostic method for this condition.
Authors
- Runzhi Yu
- Xiaona Hu
- Xuechun Zhang
- Ying Cheng
- Yiqin Huang
Institutions
- Fudan University (CN)
- Huadong Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1371/journal.pone.0332881
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00