Early vascular toxicity induced by Bothrops atrox venom in the chorioallantoic membrane assay: Kinetic profile and translational insights
B. atrox venom rapidly compromises vascular integrity and triggers an inflammatory response in the CAM model, reflecting key pathophysiological features of envenomation. The severity of these effects was proportional to the duration of exposure and the venom dose used. These findings support the use of CAM assay as a translational tool for screening venom-induced vascular toxicity and underscore the imperative of early antivenom administration.
Authors
- Dabor Resiere (ORCID: https://orcid.org/0000-0001-9144-7323)
- Zakaria Boujhoud (ORCID: https://orcid.org/0000-0002-9161-5304)
- Marwa Lakhrem
- Hatem Kallel (ORCID: https://orcid.org/0000-0002-5663-0349)
- Manel Mallouli
- Stéphanie Houcke
- Majed Kammoun
- Marwa Bouhamed
- Jean Marc Pujo
- Said Hilali
- Ibtissem Ben Amara
- Sanah Essayagh
Institutions
- University of Sfax (TN)
- University of French Guiana (GF)
- National School of Business and Management in Settat (MA)
- Centre Hospitalier Universitaire de Martinique (MQ)
- Université Hassan 1er (MA)
- Centre of Biotechnology of Sfax (TN)
- Hopital Universitaire Habib Bourguiba (TN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1371/journal.pntd.0013969
- Primary Topic
- Venomous Animal Envenomation and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00