Primary Amoebic Meningoencephalitis caused by Complement C2 Deficiency
Our study demonstrates that PAM can be caused by a monogenic inborn error of immunity (IEI) and that the complement system is critical for human immunity against <i>Naegleria fowleri</i>.
Authors
- Mariana X. Byndloss (ORCID: https://orcid.org/0000-0002-2122-4156)
- José Miguel Rubio Muñoz
- Catherine L. Shelton (ORCID: https://orcid.org/0000-0002-6155-4600)
- Pilar Zamarrón
- Janet Markle.
- Isabel de Fuentes Corripio
- Naima Amenzoui (ORCID: https://orcid.org/0009-0001-5904-9912)
- Rubén Martínez Barricarte
- Cui Jian
- Colleen M. Roark (ORCID: https://orcid.org/0009-0002-3312-5312)
- P. Nozal Aranda
- Megan Dobrose (ORCID: https://orcid.org/0009-0005-9180-1018)
- Santiago Rodríguez de Córdoba
- Dante Reyna
- Luis Ignacio Gonzalez-Granado
- C. Henrique Serezani
- Begona Losada
- Jacob Lorenzo-Morales
- Rebeca Perez de Diego
Institutions
- Universidad Complutense de Madrid (ES)
- Howard Hughes Medical Institute (US)
- Universidad de La Laguna (ES)
- Hospital Universitario La Paz (ES)
- Instituto de Salud Carlos III (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Centro Nacional de Microbiologia (ES)
- Hospital La Paz Institute for Health Research (ES)
- Hospital Virgen de la Salud (ES)
- Parc de Salut (ES)
- Complejo Hospitalario Universitario de Toledo (ES)
- Universidad Autónoma de Madrid (ES)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-02
- DOI
- https://doi.org/10.64898/2026.01.31.26345168
- Primary Topic
- Legionella and Acanthamoeba research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vanderbilt University
- National Institutes of Health
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases