Clonal relatedness and emerging linezolid resistance in Clostridioides difficile ribotypes 001 and 176 in the Czech Republic

RT001 and RT176 predominate in the Czech Republic, and WGS confirmed their inter-hospital clonal relatedness. Importantly, the emergence of linezolid-resistant RT001 strains was detected in nine hospitals. The inclusion of AMR genes in genetic relatedness analysis showed higher discriminatory power compared to cgMLST or wgMLST alone.

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Publication Details

Journal
International Journal of Infectious Diseases
Published
2026-02-03
DOI
https://doi.org/10.1016/j.ijid.2026.108444
Primary Topic
Clostridium difficile and Clostridium perfringens research
Type
article
Field-Weighted Citation Impact
0.00

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article

Clonal relatedness and emerging linezolid resistance in Clostridioides difficile ribotypes 001 and 176 in the Czech Republic

Ivana Vítková, Ježek Petr, D. Pavel, Czyžová Erika et al.
International Journal of Infectious Diseases
Clostridium difficile and Clostridium perfringens research
article

Clonal relatedness and emerging linezolid resistance in Clostridioides difficile ribotypes 001 and 176 in the Czech Republic

Ivana Vítková, Ježek Petr, D. Pavel, Czyžová Erika, Kinross Pete, Zamazalova Dana, Brajerova Marie, Krutova Marcela, Bartonikova Natasa, Ryskova Lenka, Vagnerova Iva, Vesela Denisa, Kadleckova Zuzana, Prokopova Tereza, Melichar Antonin, Nycova Elka, Havlinova Lenka, Balejova Magda, Geigerova Lenka, Curdova Martina, Miskova Eliska, Kucharova Alice, Nyc Otakar, Skruzna Marketa, Simeckova Eva, Tejkalova Renata
article en

Abstract

RT001 and RT176 predominate in the Czech Republic, and WGS confirmed their inter-hospital clonal relatedness. Importantly, the emergence of linezolid-resistant RT001 strains was detected in nine hospitals. The inclusion of AMR genes in genetic relatedness analysis showed higher discriminatory power compared to cgMLST or wgMLST alone.

International Journal of Infectious DiseasesVol. 165
Technical University of Liberec (CZ), Tomas Bata University in Zlín (CZ), OSRAM (United States) (US), Charles University (CZ), Masaryk University (CZ), Fakultní nemocnice Bulovka (CZ), University Hospital in Motol (CZ), Public Health Institute Ostrava (CZ), Institute of Microbiology (BY), University Hospital Brno (CZ), Havlíčkův Brod Hospital (CZ), University Hospital Olomouc (CZ), SHM (Czechia) (CZ), Nemocnice České Budějovice (CZ), Institute of Clinical and Experimental Medicine (CZ), Military University Hospital Prague (CZ), St. Anne's University Hospital Brno (CZ), University Hospital Hradec Králové (CZ), Racom (Czechia) (CZ), Strakonice Hospital (CZ), Thomayer University Hospital (CZ), Nemocnice Jindřichův Hradec (CZ), Nemocnice Třebíč (CZ), Palacký University Olomouc (CZ)
European Commission, Ministerstvo Zdravotnictví Ceské Republiky
Reduced inequalities
Openalex Percentile: Top 68%
Clostridium difficile and Clostridium perfringens research
DOIOpen Access PDFOpenAlex
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