Unmodified γδ T cells exhibit potent antitumor activity in hepatocellular carcinoma and are enhanced by PD-L1 blockade
Unmodified γδ T cells demonstrate strong antitumor activity and a favorable safety profile in HCC but are limited by adaptive PD-L1-mediated immune resistance in PD-L1-positive tumors. These findings provide a mechanistic rationale for combining γδ T cell-based therapies with immune checkpoint inhibition to enhance therapeutic efficacy in advanced HCC.
Authors
- Kaiyun Chen
- Hong-Yi Lin (ORCID: https://orcid.org/0000-0002-4623-0819)
- Bo-Xiang Benjamin Zhang
- Hoang Yen Tran
- Chung-Che Wu
- Tsung-I Hsu
- Chih-Jie Shen
Institutions
- Can Tho University (VN)
- Taipei Medical University Hospital (TW)
- University of Medicine and Pharmacy at Ho Chi Minh City (VN)
- Institute of Biomedical Sciences, Academia Sinica (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Immunobiology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1016/j.imbio.2026.153163
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00